The Detroit Lions (4-1) and Kansas City Chiefs (2-2) will square off on “Sunday Night Football” in Week 6, in an interconference battle between two of the best teams in the NFL. The defending AFC Champions will host Detroit for the second time in the Dan Campbell era; the first happened in 2023 when the Lions upset the Chiefs 21-20 in the 2023 season opener.

The Kansas City Chiefs got off to a rough start in 2025, beginning the season 0-2 after losses to the Chargers and Eagles, but wins over the Giants and Ravens evened them up to 2-2. They have yet to play in Week 5—they play the Jaguars on “Monday Night Football”—but that won’t stop Vegas from looking ahead. The folks over at FanDuel Sportsbook are ready to make their projections for Week 6, and they’ve set the opening betting line at

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