Mary E Brunkow, Fred Ramsdell and Shimon Sakaguchi have won the Nobel Prize in medicine for their discoveries concerning peripheral immune tolerance.

The trio will be formally awarded the prize, officially known as the Nobel Prize in Physiology or Medicine, during a ceremony on December 10.

Peripheral immune tolerance is one way the body helps keep the immune system from getting out of whack and attacking your own tissues instead of foreign invaders.

Monday's announcement took place in Stockholm.

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