Week 6 of the NFL and fantasy football season is finally here as fantasy managers continue to make pivotal adjustments that will set their teams up for success in the rest of the season. Among a number of wild upsets, including a bizarre finish in the Tennessee Titans vs. Arizona Cardinals game, Week 5 was one of the higher-scoring weeks of the season thus far. Making solid fantasy decisions at the D/ST slot could make or break your weekly matchup, so be sure to follow trends in an ever-changing league.

After numerous injuries and depth chart moves throughout the last week, offenses and defenses will need to adjust to the weekly change of the NFL landscape. We'll take a look at some key D/ST to start this week, along with some defenses you should look to avoid.

Week 6 D/ST – Start ‘Em

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