There's another heavy slate of inter-conference matchups to place Week 6 NFL bets on as there's only one Sunday divisional game. Patriots vs. Saints (+3.5), Colts vs. Cardinals (+6.5), Jaguars vs. Seahawks (-1.5) and Chiefs vs. Lions (+2.5) on SNF are just some of those contests, while if searching for a larger Week 6 NFL spread, there's Bengals vs. Packers (-14). You could not only target these games with football picks or a Week 6 NFL parlay, but the stars that make up those teams like Stefon Diggs, Jonathan Taylor, Patrick Mahomes and Jahmyr Gibbs could factor into NFL DFS picks, in Week 6 Fantasy football lineups, or in NFL player props.

A Week 6 NFL betting guide would cover all bases and help make your betting slip a profitable one. Being aware of statistical trends, recent injuries

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