Week 6 of the NFL season gets underway with a matchup of NFC East rivals when the Philadelphia Eagles visit the New York Giants on "Thursday Night Football."

The Eagles are coming off their first loss of the season, 21-17 to the Denver Broncos , in which they were outscored 18-0 in fourth quarter.

The Giants, meanwhile, dropped to 1-4, losing to a previously winless New Orleans Saints team.

Philadelphia, the odds-on favorite in the NFC East (-225), won both matchups with the Giants last season and is a 7.5-point favorite in Thursday's matchup. Saquon Barkley has the best odds to score a touchdown at -155.

Here are the odds and trends, plus picks, props and analysis from our experts to help you bet the game.

Note: Odds at time of publication. For the latest updates, visit

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