A week after seizing control of the AFC South with a shootout victory over the Seattle Seahawks 38-35, the Tampa Bay Buccaneers will face another stiff test when they battle the NFC West-leading San Francisco 49ers (+3). San Francisco is coming off a 26-23 victory over the Los Angeles Rams on Thursday Night Football. The Buccaneers are 2-1 in the conference, while the 49ers are 4-0 against NFC foes. There are a number of intriguing matchups on the Week 6 NFL schedule, including Broncos vs. Jets (+7.5) in London, Rams vs. Ravens (+7.5), with Lamar Jackson's availability uncertain, Seahawks vs. Jaguars (-1.5), Lions vs. Chiefs (-2.5) on Sunday Night Football and Bears vs. Commanders (-4.5) on Monday Night Football.
Which other teams have value to include in Week 6 NFL parlay bets, and which