The Brief

PHOENIX - Following a stunning loss, the Arizona Cardinals will look to break their losing streak this week on the road against one of the best teams in the NFL.

What Happened Last Week:

The Cardinals blew a 21-6 lead , eventually losing on a game-winning field goal to the then-winless Tennessee Titans at State Farm Stadium in Glendale. The Cardinals (2-3) have lost three straight after winning their first two games.

This Week:

In Week 6, Arizona faces the Indianapolis Colts (4-1), who lead their division and are the current top seed in the AFC.

Dig deeper:

The Cardinals could be without Kyler Murray, who was injured in last week's game. Head coach Jonathan Gannon said if Murray can't play, backup Jacoby Brissett would start against the Colts .

Big picture view:

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