“Grey’s Anatomy” fans have waited agonizing months for the resolution to season 21’s cliffhanger finale, and it’s finally here when “Grey’s Anatomy” Season 22 premieres Thursday, October 9 (10/9/2025) at 10 p.m. ET on ABC. But one thing’s for sure, not everyone’s will survive the episode.
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A gas explosion at the end of last season left fans’ hearts pounding, and trailers for the new season make it clear that a main character death is looming over the series.
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