Kyler Murray's foot injury appears to be a bigger issue than previously thought.

The Arizona Cardinals quarterback briefly exited because of the injury in a 22-21 Week 5 loss to the Tennessee Titans but returned to the game. However, Pro Football Talk's Josh Alper reported Murray missed a second straight practice on Thursday.

On Wednesday, Cardinals head coach Jonathan Gannon said Murray is considered "day-to-day," via Alper. If he doesn't practice Friday, he would likely be sidelined for Sunday's road game against the Indianapolis Colts at 1 p.m. ET on Fox.

ESPN's Jeremy Fowler added that Murray is considered a "close call." As such, the Cardinals are preparing for either Murray or Jacoby Brissett to start.

As of now, Kyler Murray is shaping up to be a close call. Cardinals w

See Full Page