Week 6 got underway with a matchup of NFC East rivals as the Philadelphia Eagles were upset 34-17 by the New York Giants on "Thursday Night Football." The Eagles, who had won both matchups last season, were 7.5-point favorites.

Sunday features an intriguing matchup of 4-1 teams, with the Tampa Bay Buccaneers (-2.5) hosting the San Francisco 49ers , and concludes with the Kansas City Chiefs (-1.5) taking on the Detroit Lions .

The week finishes with a Monday night doubleheader, leading off with the Buffalo Bills (-3.5)facing the Atlanta Falcons and wrapping up with the Chicago Bears visiting the Washington Commanders (-4.5).

It's a bye week for a pair of teams, as the Minnesota Vikings , fresh off two international games, and the Houston Texans are resting.

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