The top Week 6 defense streamers - fantasy football D/ST pickups, streamers and starts for 2025. Target these fantasy DST streaming options with strong matchups.

Targeting the right defense could be the difference between you losing and winning your fantasy matchup. This past weekend, several defensive units, such as the Houston Texans and the Washington Commanders, enjoyed strong showings, which likely played a key role in managers securing a victory.

This weekend, he has several intriguing options to target, and with over a month of data to analyze, we can identify the optimal defensive units to stream.

Who should fantasy managers look to target on the waiver wire and plug into their starting lineup? Let's dive in! Be sure to check all of our fantasy football rankings for 2025:

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