Spoilers for the season 22 premiere of Grey’s Anatomy ahead.

Camilla Luddington wanted fans to keep the tissues at the ready.

With Grey’s Anatomy season 21 ending in May with a shocking explosion on the surgical floor—and many Grey Sloan Memorial doctors unaccounted for—it was only fitting for season 22 to begin with the fallout. By the Oct. 9 episode’s end, not all the doctors had made it out alive, with Dr. Monica Beltran ( Natalie Morales ) ultimately succumbing to her injuries . And though her death may have shocked viewers, series mainstay Camilla had previously teased the tragedy to come.

"You know, there are some season premieres that I'm excited to come back and film," the actress behind Dr. Jo Wilson exclusively told E! News in August. "And this one, and I think I

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