The No. 21 Iowa State Cyclones (5-1, 2-1 Big 12) visit the Colorado Buffaloes (2-4, 0-3) on Saturday. Kickoff from Folsom Field in Boulder, Colorado, is at 3:30 p.m. ET (ESPN). Let's analyze BetMGM Sportsbook's NCAA football odds around the Iowa State vs. Colorado odds and make our expert college football picks and predictions for the best bets.

Iowa State suffered its first loss of the season last week, 38-30 on the road to the Cincinnati Bearcats as 1-point underdogs as the Over (56.5) cashed. Cincinnati built a 31-7 first-half lead and held on as Iowa State made it a one-score game. The Cyclones allowed 260 rushing yards and 3 rushing TDs.

The Buffaloes have lost 2 games in a row. Last week, they were defeated 35-21 on the road by the TCU Horned Frogs, failing to cover t

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