Quarterback injuries throw everything for a loop in the NFL , and that's certainly been the case in the early stages of 2025. That remains the case for Week 6, but signal-callers aren't the only big injuries worth monitoring this weekend. If you're interested in NFL betting , you need to be aware of who's in and who's out before you place any Week 6 bets of your own.

Here, we break down the biggest NFL injuries to know for all of the Week 6 games on Sunday and Monday, including where lines currently stand, according to the latest SportsLine consensus odds , which uses the latest data and odds from top sportsbooks . This post will be updated as official inactives lists are announced before kickoff.

Denver Broncos vs. New York Jets (9:30 a.m. ET, in London)

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