No. 21 Iowa State football continues its 2025 season on Saturday, Oct. 11, with a Big 12 Conference road game against Deion Sanders' Colorado Buffaloes .

The Cyclones (5-1, 2-1 Big 12) are coming off a disappointing 38-30 loss at Cincinnati.

The Buffaloes (2-4, 0-3) are on a two-game losing streak, most recently falling 35-21 at TCU.

Here are some predictions and the betting lines for the game: Stream Iowa State vs. Colorado for free with Fubo Expert MLB daily picks: Unique MLB betting insights only at USA TODAY

Iowa State vs. Colorado odds, moneyline, over/under

Odds courtesy of BetMGM as of Friday evening.

Spread : Iowa State -2.5

Moneyline: Iowa State -140, Colorado +120

Over/under : 52

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