The Kansas City Chiefs (2-3) are set to host the Detroit Lions (4-1) in NFL Week 6 action on 'Sunday Night Football.' Patrick Mahomes and the Chiefs are off to a bumpy start this season, and are coming off of a disappointing 31-28 loss to the Jacksonville Jaguars in Week 5. Meanwhile, Jared Goff and the Lions have won four straight since falling to the Green Bay Packers in Week 1, most recently topping the Cincinnati Bengals 37-24.

Kickoff from Arrowhead Stadium is set for 8:20 p.m. ET. Kansas City is a 2.5-point favorite in the latest Lions vs. Chiefs odds, and the over/under for total points scored is 52.5. Before making any Chiefs vs. Lions picks, be sure to see what the SportsLine projection model has to say .

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