The Indianapolis Colts are one of the NFL's best storylines early in the 2025 season. Daniel Jones' renaissance has led the Colts to a 4-1 start. Now Indy will look to extend their winning streak against the Cardinals. But they will have to make it work without two backup offensive players.

The Colts made a number of surprising inactives moves before Sunday's game against the Cardinals.

Indy announced that Anthony Richardson is now the team's third-string quarterback after suffering an eye injury during pregame warmups . Riley Leonard will take over as the Colts backup quarterback in Week 6.

Meanwhile, the Colts also listed wide receiver Adonai Mitchell as a healthy inactive for Sunday's game, per Ari Meirov of The 33rd Team.

Mitchell only played in garbage time in last wee

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