JOHANNESBURG — South Africa's health minister on Tuesday called lenacapavir, the first twice-yearly HIV prevention jab in the world, a “groundbreaking” tool to fight the disease, but warned initial donated supply would be limited to nearly half a million people in the African country with the highest prevalence rate.

This comes just weeks after the U.S. announced plans to buy 2 million doses of the HIV prevention drug for low-income countries.

The initial supply in South Africa is set to begin in April 2026, funded by a $29.2 million Global Fund grant with an additional $5 million allocated by the Networking HIV and AIDS Community of Southern Africa (NACOSA).

Addressing a national healthcare roundtable dialogue in Johannesburg, Minister Aaron Motsoaledi said the Global Funds’ catalytic

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