A dream start to the season for the San Francisco 49ers , winning despite multiple injuries to impact players on both sides of the ball, could potentially result in a nightmare.

The 49ers lost to the Tampa Bay Buccaneers in Week 6, 30-19, but the more significant news is that they lost the leader of their defense, Fred Warner , to a s eason-ending ankle injury . The expectations of the season for San Francisco have changed due to injuries to key players.

With two of the top three defenders on the roster out for the season in Nick Bosa and Warner, it will be tough for the 49ers to build on their great start. They will have to rely on younger players, including linebackers Dee Winters, Tatum Bethune and Nick Martin, defensive back Upton Stout and defensive linemen Mykel Willi

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