Brandon's DraftKings and FanDuel UCL DFS lineup picks for UEFA Champions League Soccer on 10/21/25 (Matchweek 3, Day One). His top daily fantasy soccer forwards, midfielders, defenders, goalkeepers.

Welcome back to “The Kick-Off” and welcome to the 25-26 season! After another run of International Play, followed by Domestic play at the weekend, we start Matchweek Three! There is a high chance of heavy rotation with the slew of fixtures over the last two weeks! Let's knock out Matchweek Three!!

The top favorite for today is Arsenal FC (-185) vs. Atlético Madrid (+500). I will guide you through this seven-match slate starting at 3 :00 P.M. EST on Wednesday, October 21.

If you have any questions on today's slate, bankroll management, GPP strategy, Cash game strategy, or anything else,

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