The Cleveland Cavaliers and the New York Knicks open their season Wednesday at Madison Square Garden in New York. Tip-off is scheduled for 7 p.m. ET (ESPN). Let's analyze BetMGM Sportsbook's NBA odds around the Cavaliers vs. Knicks odds and make our expert NBA picks and predictions for the best bets.

2024-25 season series: Cavaliers won 4-0

The Cavaliers picked up 4 victories in 4 tries last season against the Knicks including a pair of 6-point victories at Madison Square Garden. Cleveland was an underdog in each of those meetings, and the Cavaliers were 4-0 against the spread (ATS) in each of those matchups, too. The Under went 3-1 in the 4 meetings, while cashing at a 9-1 clip in the past 10 installments since a playoff game April 21, 2023.

Cleveland won 64 games last se

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