The New York Knicks will host the Cleveland Cavaliers on Wednesday as the Eastern Conference contenders tip off their 2025-26 NBA seasons. Cleveland had the East's best record at 64-18 last year before bowing out in the second round of the playoffs. New York went 51-31 and advanced to the East Finals before losing to Indiana and then replacing Tom Thibodeau with Mike Brown at head coach. The Cavs swept the season series between the squads last year, winning all four games.

Tipoff is at 7 p.m. ET from Madison Square Garden in New York City, where the Knicks went 27-14 last season. Cleveland is a 1.5-point favorite in the latest Cavaliers vs. Knicks odds, while the over/under for total points scored is 228.5. Before locking in any Knicks vs. Cavaliers picks, make sure to check out the

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