A historic north-west Victorian pub has been destroyed by fire a century after it was rebuilt following a previous blaze.

Four people, including the two owners, a staffer and a resident, escaped unharmed after fire engulfed the two-storey Lascelles Minapre Hotel overnight.

Eleven fire crews were called to the pub at Lascelles, on the Henty Highway south of Mildura, just after 2am to find the 119-year-old building well alight.

Limited water access resulted in responses from the Mildura and Sea Lake brigades who brought an aerial unit, and extra tankers and pumpers.

CFA incident controller Daniel Floyd told ABC Wimmera the community had lost its meeting place.

"The bottle shop is left, a couple rooms out the back and the kitchen. But that's about it,"

Mr Floyd said.

"It's very, very d

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