49ers starting quarterback Brock Purdy again was a limited participant in practice. He was limited all of last week and ruled out against the Falcons.
Purdy, who has turf toe, has not had a full practice since Sept. 26.
He initially injured his toe in Week 1 and missed two weeks before returning for Week 4. He missed every practice in Weeks 5-6.
Mac Jones, who was a full participant on Wednesday with knee and oblique injuries, has started five games and has a 4-1 record.
The 49ers did not have center Jake Brendel (hamstring), defensive end Yetus Gross-Matos (knee/hamstring), defensive end Bryce Huff (hamstring), cornerback Deommodore Lenoir (quad), running back Christian McCaffrey (rest), wide receiver Ricky Pearsall (knee) or left tackle Trent Williams (rest) at Wednesday’s practice.