The Philadelphia 76ers open the 2025-26 NBA season at the TD Garden, hoping to avoid a fourth straight loss against the Boston Celtics.

How to Watch 76ers vs Celtics

Date: Wednesday, October 22, 2025

Time: 7:30 PM EDT

Channel: NBC Sports Boston

Stream: Fubo ( try for free )

Boston raises the curtain on its 2025/26 NBA campaign at home to Philadelphia, hoping to continue an imperious streak of form against the 76ers. The Celtics beat their Atlantic Division rivals no fewer than three times last season and are back at TD Garden in the hopes of extending that run.

Yet despite the reason dominance in this head-to-head, Boston enters the midweek matchup as a slim two-point favorite to beat Philadelphia. That’s despite a 1-3 pre-season run that ended with a consolatory win over Minnes

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