Researchers discover that mRNA vaccines can enhance the immune response against tumours when combined with immunotherapy

xAustin: The COVID-19 mRNA-based vaccines that saved 2.5 million lives globally during the pandemic could help spark the immune system to fight cancer. This is the surprising takeaway of a new study that we and our colleagues published in the journal Nature. While developing mRNA vaccines for patients with brain tumours in 2016, our team, led by pediatric oncologist Elias Sayour, discovered that mRNA can train immune systems to kill tumours even if the mRNA is not related to cancer. Based on this finding, we hypothesised that mRNA vaccines designed to target the SARS-CoV-2 virus that causes COVID-19 might also have antitumor effects. So we looked at clinical outcome

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