VDOT officials said the crash closed I-64's right lane and shoulder at mile marker 186. That is near the exit for Staples Mill Road as well as the exit for Laburnum Avenue and I-195.
The semi driver suffered injuries that were described as non-life-threatening.
Traffic was backed up just over 2 miles as of 11:05 a.m.
"Extended closures are anticipated," VDOT officials warned. "Motorists should seek alternate routes to avoid delays."
The cause of the wreck remains under investigation, troopers said.

WTVR CBS 6
WIRC Richmond
SOFREP
LiveNOW from FOX Crime
NECN Entertainment
The Babylon Bee
Local News in D.C.
TheFashionCentral
Bored Panda
The Travel