The Texans will host the 49ers in a battle of teams that aren't currently operating at full strength. It's safe to say that San Francisco has been heavily impacted by the injury bug in 2025. Brock Purdy , Brandon Aiyuk , Fred Warner , and Ricky Pearsall are just some of the 49ers that are currently sidelined. Still, San Francisco has managed to produce a 5-2 record. The 49ers came away with a hard-fought 20-10 win against the Atlanta Falcons in Week 7.

Meanwhile, the Texans haven't been as fortunate to begin the 2025 campaign. Houston has started 2-4 and is fresh off a 27-19 loss at the hands of the Seattle Seahawks . To make matters worse, the Texans could be without star wide receiver Nico Collins , who suffered a concussion against the Seahawks.

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