The Colorado Buffaloes (3-4) travel to take on the Utah Utes (5-1) in a Big 12 showdown on Saturday. The Buffs are coming off what was arguably the program's biggest win under head coach Deion Sanders, when they beat then-No. 22 Iowa State 24-17 on Oct. 11. The Utes are looking to rebound from a hard-fought 24-21 loss to in-state rival BYU in the 2025 'Holy War.' Utah is 5-2, while CU is 4-3 against the spread in 2025.

Kickoff from Rice-Eccles Stadium in Salt Lake City is set for 10:15 p.m. ET. After opening at -14.5, the Utes are now 14-point favorites in the latest Utah vs. Colorado odds, while the over/under for total points scored is 49.5. Before making any Colorado vs. Utah picks, make sure you check out what SportsLine college football expert Jimmie Kaylor has to say .

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