Jax State's Cam Cook tries to evade the tackle of Murray State's John Ford during college school football action at AmFirst Stadium in Jacksonville, Alabama September 20, 2025. (Dave Hyatt / Hyatt Media LLC)

Week 10 continues to get rolling on Wednesday night as Conference USA continues its weeknight treat for college football fans to tune into to get their fix.

The Middle Tennessee Blue Raiders (1-6, 0-3 CUSA) will host the Jacksonville State Gamecocks (4-3, 3-0 CUSA), who are tied atop the conference standings, from Johnny "Red" Floyd Stadium in Murfreesboro, Tennessee.

If you are looking for some betting advice for the matchup, we've got you covered. Here are the latest odds for the game, courtesy of BetMGM.

Stream Jacksonville State vs. Middle Tennessee

Jacksonville State vs. Middle Tennessee game odds

All college football odds via BetMGM

  • Spread: Jacksonville State - 6.5 (-110), Middle Tennessee +6.5 (-110)
  • Money Line: Jacksonville State -220, Middle Tennessee +185
  • Over-Under: Over 57.5 (-110), Under 57.5 (-110)

Jacksonville State vs. Middle Tennessee prediction, pick:

On the one hand, Middle Tennessee is close. The last three losses, all conference play, have been by eight points or less. One could believe they are right there. On the other hand, some may choose to believe Middle Tennessee is finding a way to lose these close games.

Jacksonville State presents a tough test for the Blue Raiders. Sitting atop the conference standings, the Gamecocks can't drop this one to a team sitting in the cellar if they want to stay in the race, and they know that.

Jacksonville State is going to run the ball and does so extremely well with Cam Cook, the nation's leading rusher with 949 yards on the year and 10 touchdowns. Middle Tennessee is perfectly average defending the run, sitting at No. 67 in the country. They aren't bad, but to slow down Cook, they would need to be great, and that doesn't happen. Gamecocks get to 5-2 overall and stay atop the CUSA.

Prediction: Jacksonville State 34, Middle Tennessee 21

Best Bet: Jacksonville State -6.5

Jacksonville State vs. Middle Tennessee channel, start time, streaming:

Time: 7:30 p.m. ET

TV Channel: ESPN2

Live Stream: ESPN App

Get more betting analysis and predictions at Sportsbook Wire.

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This article originally appeared on College Sports Wire: Jacksonville State vs. Middle Tennessee: Week 10 College Football Betting Odds, Prediction

Reporting by Riley Donald, College Sports Wire / College Sports Wire

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