A new report commissioned by the Greater Boston Chamber of Commerce warns that federal policy changes proposed by the Trump administration could strip Massachusetts of $5.9 billion in economic output and $515 million in tax revenue — the largest per capita loss of any state.

The analysis, conducted by Econsult Solutions Inc., highlights the outsized role that higher education and health care play in Massachusetts’ economy. The report says these sectors are particularly vulnerable to federal cost-cutting and funding caps.

According to the report, the state’s higher education and health systems generate $155.9 billion in economic output and support more than 858,000 jobs statewide, contributing roughly $4.1 billion in tax revenue yearly.

Roughly a quarter of those jobs — about 222,900 p

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