The San Francisco 49ers are coming east in Week 9 to face the New York Giants at MetLife Stadium. Both teams lost their Week 8 matchups and are dealing with injuries to key players. Can San Francisco's defense bounce back after a rough performance in Houston? How will New York's offense change without Cam Skattebo ? We have the answers in our Week 9 49ers vs Giants bold predictions.

The Giants are now 2-6 and without two of their key offensive playmakers. Skattebo, like Malik Nabers, is out for the season. Cornerback Cor'Dale Flott and tight end Daniel Bellinger both left the Eagles matchup and remain on the injury report. As for the 49ers, their injury bug has not stopped. Brock Purdy may be back under center after missing time with turf toe.

Can the 49ers regain their winning way

See Full Page