The molecular mechanism that governs how the glucocorticoid receptor (GR) assembles into higher-order structures inside the cell, a process fundamental to how the receptor regulates gene expression, immune responses, and metabolism, has been uncovered by researchers at the Institute of Biomedicine (IBUB) of the University of Barcelona. The study, published in Nucleic Acids Research , shows that the GR forms tetramers, not just monomers or dimers as previously believed, unlocking a new, potentially fertile, ground for the development of new therapies for a range of conditions.

“The glucocorticoid receptor controls approximately 20% of the human transcriptome and is fundamental in the regulation of glycemia, metabolism and the anti-inflammatory response,” said senior author Eva Estébane

See Full Page