Louisville Cardinals quarterback Miller Moss (7) passes against the Boston College Eagles during the second half at L&N Federal Credit Union Stadium in Louisville, Kentucky.

The No. 17 Louisville Cardinals (6-1, 3-1 ACC) and Virginia Tech Hokies (3-5, 2-2) meet in a conference showdown Saturday afternoon. Kickoff from Lane Stadium in Blacksburg, Virginia, is set for 3 p.m. ET (CW Network). Let's analyze BetMGM Sportsbook's NCAA football odds around the Louisville vs. Virginia Tech odds and make our expert college football picks and predictions for the best bets.

The Cardinals beat the Boston College Eagles 38-24 Saturday, failing to cover as a 26-point home favorite as the Over (54) cashed. The game prior, a 24-21 road win over No. 9 Miami Hurricanes, was Louisville's staple victory of the season. Its lone loss came at home in overtime to the Virginia Cavaliers in Week 6. Through 7 games, the Cardinals are 2-5 against the spread (ATS) and 4-3 O/U.

Virginia Tech, a program gaining some buzz as a potential destination for former Penn State coach James Franklin, beat the Cal Bears 42-34 in overtime at home on Oct. 24 in Week 9. It closed as a 6-point favorite as the Over (50.5) hit. Virginia Tech snapped a 2-game losing streak with the victory. Despite that, it has struggled to meet expectations and is just 2-6 ATS on the season.

Virginia Tech leads the all-time series 22-11 and won 42-21 last season.

– Rankings: US LBM Coaches Poll, conducted by the American Football Coaches Association and USA TODAY Sports

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Louisville at Virginia Tech odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Friday at 6:01 p.m. ET.

  • Moneyline (ML): Louisville -425 (bet $425 to win $100) | Virginia Tech +325 (bet $100 to win $325)
  • Against the spread (ATS): Louisville -10.5 (-115) | Virginia Tech +10.5 (-105)
  • Over/Under (O/U): 52.5 (O: -110 | U: -110)

Louisville at Virginia Tech picks and predictions

Prediction

Louisville 34, Virginia Tech 24

Moneyline

PASS.

There's no value here. Louisville (-425) should come out on top but is far too expensive to consider.

Against the spread

BET VIRGINIA TECH +10.5 (-105).

The Cardinals are a CFP-contending team, but they haven't played like it. Louisville is just 1-5 ATS as a favorite this season and 0-4 ATS as a double-digit favorite. It has scored more than 27 points just once in its last 3 games, suggesting it might struggle to pull ahead by a sizable margin.

The Hokies have yet to be a home underdog. They are 2-2 ATS in their last 4 games and are 1-1 ATS in their last 2 as an underdog. Virginia Tech has scored at least 23 points in 5 of its last 6 games. Expect the home side to keep things close and back VIRGINIA TECH +10.5 (-105).

Over/Under

BET OVER 52.5 (-110).

Both teams have efficient and consistent offenses. The Cardinals have scored at least 24 in every game and are 4-3 O/U on the season. They have also allowed at least 21 in every ACC battle.

The Hokies are 2-1 O/U in their last 3 games and have given up at least 30 points in each of those as well. Considering those trends, back OVER 52.5 (-110).

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This article originally appeared on Sportsbook Wire: Louisville Cardinals at Virginia Tech Hokies odds, picks and predictions

Reporting by Nathan Beighle, Sportsbook Wire / Sportsbook Wire

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