Nov 9, 2024; Kansas City, Missouri, USA; Iowa State Cyclones helmets on the bench during the first quarter against the Kansas Jayhawks at GEHA Field at Arrowhead Stadium. Mandatory Credit: William Purnell-Imagn Images

If one thing is a certainty in life, it is that the college football season is never going to play out the way you predict, and such is evidenced by a Big 12 matchup this week.

In a rematch of last year's Big 12 title game, the Iowa State Cyclones (5-3, 2-3 Big 12) host the Arizona State Sun Devils (5-3, 2-3 Big 12) in a matchup of two teams that entered the year with playoff hopes, only for those to be dashed early.

If you are looking for some betting advice for the matchup, we've got you covered. Here are the latest odds for the game, courtesy of BetMGM.

Stream Iowa State vs. Arizona State

Iowa State vs. Arizona State game odds

All college football odds via BetMGM

  • Spread: Iowa State -8.5 (-105), Arizona State -8.5 (-115)
  • Money Line: Iowa State -235, Arizona State +260
  • Over-Under: Over 48.5 (-105), Under 48.5 (-115)

Iowa State vs. Arizona State prediction, pick:

Man, what a quarterback matchup this game could have been. Iowa State quarterback Rocco Becht and Arizona State quarterback Sam Leavitt were riding high preseason, but things have not worked out so far this year.

This week, Leavitt will be out against Iowa State, and that could prove to be a massive difference in this game if Iowa State can get out of its own way. The Cyclones have lost three straight, and things are a bit blah in Ames right now.

The issue for Iowa State has been the defense, which has been tormented for more than 34 points per game during this losing streak. Fortunately, Sam Leavitt is out, and the Sun Devils' best wide receiver, Jodryn Tyson, remains questionable.

Arizona State will lean on Raleek Brown, who has had a strong year rushing for 706 yards and three scores, but they may not have much help elsewhere.

In a game of two teams who had much higher hopes entering the year, the Cyclones at least punch their ticket to a postseason bowl berth, salvaging something.

Prediction: Iowa State 27, Arizona State 17

Best Bet: Iowa State -8.5

Iowa State vs. Arizona State channel, start time, streaming:

Time: 1 p.m. ET

TV Channel: TNT

Live Stream: HBO MAX

Get more betting analysis and predictions at Sportsbook Wire.

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This article originally appeared on College Sports Wire: Iowa State vs. Arizona State: Week 10 College Football Betting Odds, Prediction

Reporting by Riley Donald, College Sports Wire / College Sports Wire

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