Around this time last month, a Penn State-Ohio State matchup would have been touted as a Game of the Year contender with heavy playoff and championship implications.

Weeks later, the Penn State Nittany Lions ’ 2025 campaign has become a free fall as they travel to Columbus to face the No. 1-ranked Buckeyes with an interim head coach and an eye toward the future. Still, those on the field have had this game circled, and won’t back down easily at a chance to compete with one of the top teams in the country.

As the game draws closer, anticipation builds, and sportsbooks are ready to capitalize. There are already numerous betting markets available across the top sportsbooks for those looking to wager on the game.

Oddsmakers favor Ohio State by 19.5 to 20 points across the top Pennsylvani

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