LOUISVILLE, Ky. (WDRB) – Louisville running backs coach Chris Barclay calls his backfield “Thunder Over Louisville.”

Isaac Brown brings the fireworks. Keyjuan Brown brings the boom.

Together, they delivered an explosive and bruising performance Saturday afternoon in Blacksburg, Va., powering No. 16 Louisville to a 28-16 road win at Virginia Tech — the Cardinals’ fourth straight road victory and a crucial ACC result on a day when Miami dropped its second conference game.

Isaac Brown ran for 126 yards and a touchdown on 16 carries. Keyjuan Brown ran for 94 yards and two touchdowns on 12 carries. Caullin Lacy had more than 100 yards on three punt returns and Louisville ran for 231 yards on the ground.

But an apparent hamstring injury to Isaac Brown in the fourth quarter could keep t

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