Kansas City Chiefs at Buffalo Bills odds, picks and predictions

(L-R) Buffalo Bills quarterback Josh Allen greets Kansas City Chiefs quarterback Patrick Mahomes following a 2024 AFC Divisional Round playoff game at Highmark Stadium in Orchard Park, New York.

The Kansas City Chiefs (5-3) visit the Buffalo Bills (5-2) in a Week 9 matchup with AFC Championship Game preview potential. Kickoff from Highmark Stadium in Orchard Park, New York, is set for 4:25 p.m. ET (CBS). Let's analyze BetMGM Sportsbook's NFL odds around the Chiefs vs. Bills odds and make our expert NFL picks and predictions for the best bets.

The Chiefs dominated a Jayden Daniels-less Washington Commanders team 28-7 last week, covering as 10-point home favorites. QB Patrick Mahomes was 25-for-34 for 299 yards, 3 TDs and 2 INTs. RB Kareem Hunt had a rushing and receiving touchdown. He'll see a bigger role this week as RB Isiah Pacheco (knee) went down with a sprained MCL.

The Bills destroyed the Carolina Panthers 40-9 as 7.5-point road faves last week. QB Josh Allen was 12-for-19 for 163 yards, 1 TD and 0 INTs before he took a seat. He also ran 2 scores in. Speaking of, RB James Cook had a monster day with 216 yards on 19 carries and 2 scores of his own.

These teams have split the last 10 meetings 5-5.

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Chiefs at Bills odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 12:42 p.m. ET.

Moneyline (ML): Chiefs -130 (bet $130 to win $100) | Bills +110 (bet $100 to win $110)
Against the spread (ATS): Chiefs -2 (-110) | Bills +2 (-110)
Over/Under (O/U): 52.5 (O: -110 | U: -110)

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Chiefs at Bills key injuries

Chiefs

OL Jaylon Moore (illness) questionable
RB Isiah Pacheco (knee) out
OL Josh Simmons (personal) out
OG Trey Smith (back) questionable

Bills

CB Taron Johnson (groin) questionable
DL DaQuan Jones (calf) out
WR Josh Palmer (knee, ankle) out
LB Shaq Thompson (hamstring) out

Chiefs at Bills picks and predictions

Prediction

Bills 24, Chiefs 21

Moneyline

I like the home side here as Bills coach Sean McDermott will have a gameplan to limit what Chiefs WR Rashee Rice does and make Mahomes go somewhere else. At (+110) plus-money, the Bills look the healthiest they have been in a while.

Take BILLS (+110).

Against the spread

Since we're taking the value on the ML, skip the spread. Give me Chiefs RB BRASHARD SMITH OVER 19.5 RECEIVING YARDS (-118). He'll be on the field a lot, especially on third downs. He's a combo back that is a former wide receiver and has good hands out of the backfield.

Over/Under

The Chiefs have cashed 3 straight Unders, and the Bills have cashed 2 of 3. These games are always tight, but 52.5 is the highest total in the last 5 matchups. It feels a little high to me.

I'll go UNDER 52.5 (-110).

For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

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This article originally appeared on Sportsbook Wire: Kansas City Chiefs at Buffalo Bills odds, picks and predictions

Reporting by Ryan Dodson, Sportsbook Wire / Sportsbook Wire

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