Daijiworld Media Network - Mumbai

Mumbai, Nov 7: Recent research has shown that genetic risk factors in systemic lupus erythematosus (SLE) can influence the emergence of specific clinical features, shedding light on disease heterogeneity and potential personalized care approaches. Investigators analyzed population and clinical datasets, aligning public biobank records with the 11 American College of Rheumatology 1982 (ACR-82) classification criteria. They examined whether higher inherited susceptibility increased the likelihood of relevant manifestations, using data from over 218,000 individuals and modeling the cumulative effect of 57 known SLE risk variants. The observations were validated in a clinical cohort of 1,487 genotyped Scandinavian patients with detailed phenotyping. Manifest

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