CRISPR gene-editing works to reduce high cholesterol in a new study

Rob Stein

November 08, 2025 / 6:58 am

A single infusion of an experimental gene-editing drug appears safe and effective for cutting cholesterol, possibly for life, according to a small early study released Saturday.

The study, which involved 15 volunteers, found one infusion of a drug that uses the CRISPR gene-editing technique could safely reduce cholesterol, as well as levels of harmful triglycerides, by about half.

"Rather than a lifetime worth of medicine, we have the potential to give people a cure," said Dr. Luke Laffin , a preventative cardiologist at the Cleveland Clinic who helped conduct the study. "It's very exciting."

The results of the study were presented Saturday at the American Heart Association'

See Full Page