Ohio State Buckeyes wide receiver Jeremiah Smith (4) runs over Purdue Boilermakers defensive back Smiley Bradford (1) during the NCAA football game at Ross-Ade Stadium in West Lafayette, Ind. on Nov. 8, 2025.

Week 12 of the 2025 college football season could provide a chance for a major shakeup of the College Football Playoff field.

Of the 25 ranked teams in the US LBM Coaches Poll, 23 of them will be in action this weekend, including a grand total of two top-10 matchups in the SEC that could shake up the entire 12-team field. No. 4 Alabama (8-1, 6-0 SEC) takes on No. 10 Oklahoma (7-2, 3-2), while No. 5 Georgia (8-1, 6-1) faces off against No. 10 Texas (7-2, 4-1).

Another key matchup will be No. 9 Notre Dame vs. No. 23 Pittsburgh, which has drawn enough attention for ESPN's "College GameDay" to return to Pittsburgh for the first time in 20 years.

As has been the case all season, any team could be on upset alert on any given Saturday. Penn State nearly knocked off No. 2 Indiana last week, while No. 14 Vanderbilt avoided an upset at the hands of Auburn in overtime.

Here is an early look at picks, predictions and odds for all of the Week 12 games on the 2025 college football schedule:

College football Week 12 game predictions, picks

Odds courtesy of BetMGM as of Sunday, Nov. 9

No. 1 Ohio State vs UCLA

  • Date: Saturday, Nov. 15
  • Time: 7:30 p.m. ET
  • Location: Ohio Stadium (Columbus, Ohio)
  • Spread: Ohio State -31.5

Prediction: Ohio State 42, UCLA 10

No. 2 Indiana vs Wisconsin

  • Date: Saturday, Nov. 15
  • Time: 12 p.m. ET
  • Location: Memorial Stadium (Bloomington, Indiana)
  • Spread: Indiana -30.5

Prediction: Indiana 38, Wisconsin 10

No. 3 Texas A&M vs South Carolina

  • Date: Saturday, Nov. 15
  • Time: Noon ET
  • Location: Kyle Field (College Station, Texas)
  • Spread: Texas A&M -18.5

Prediction: Texas A&M 34, South Carolina 16

No. 4 Alabama vs No. 10 Oklahoma

  • Date: Saturday, Nov. 15
  • Time: 3:30 p.m. ET
  • Location: Bryant-Denny Stadium (Tuscaloosa, Alabama)
  • Spread: Alabama -7

Prediction: Alabama 30, Oklahoma 28

No. 5 Georgia vs No. 10 Texas

  • Date: Saturday, Nov. 15
  • Time: 7:30 p.m. ET
  • Location: Sanford Stadium (Athens, Georgia)
  • Spread: Georgia -6

Prediction: Georgia 31, Texas 24

No. 6 Oregon vs Minnesota

  • Date: Friday, Nov. 14
  • Time: 9 p.m. ET
  • Location: Autzen Stadium (Eugene, Oregon)
  • Spread: Oregon -23.5

Prediction: Oregon 34, Minnesota 10

No. 7 Ole Miss vs Florida

  • Date: Saturday, Nov. 15
  • Time: 7 p.m. ET
  • Location: Vaught-Hemingway Stadium (Oxford, Mississippi)
  • Spread: Ole Miss -13.5

Prediction: Ole Miss 42, Florida 17

No. 8 Texas Tech vs Central Florida

  • Date: Saturday, Nov. 15
  • Time: 3:30 p.m. ET
  • Location: Jones AT&T Stadium (Lubbock, Texas)
  • Spread: Texas Tech -23.5

Prediction: Texas Tech 34, UCF 14

No. 9 Notre Dame vs No. 23 Pittsburgh

  • Date: Saturday, Nov. 15
  • Time: Noon ET
  • Location: Acrisure Stadium (Pittsburgh, Pennslyvannia)
  • Spread: Notre Dame -10.5

Prediction: Pittsburgh 34, Notre Dame 30

No. 12 Georgia Tech vs Boston College

  • Date: Saturday, Nov. 15
  • Time: 3:30 p.m. ET
  • Location: Alumni Stadium (Chestnut Hill, Massachutsetts)
  • Spread: Georgia Tech -16.5

Prediction: Georgia Tech 49, Boston College 14

No. 12 BYU vs TCU

  • Date: Saturday, Nov. 15
  • Time: 10:15 p.m. ET
  • Location: LaVell Edwards Stadium (Provo, Utah)
  • Spread: BYU -5.5

Prediction: TCU 28, BYU 21

No. 15 Utah vs Baylor

  • Date: Saturday, Nov. 15
  • Time: 7 p.m. ET
  • Location: McLane Stadium (Waco, Texas)
  • Spread: Utah -8.5

Prediction: Utah 30, Baylor 28

No. 16 Miami vs NC State

  • Date: Saturday, Nov. 15
  • Time: 7:30 p.m. ET
  • Location: Hard Rock Stadium (Miami Gardens, Florida)
  • Spread: Miami -14.5

Prediction: Miami 31, NC State 18

No. 17 Michigan vs Northwestern

  • Date: Saturday, Nov. 15
  • Time: Noon ET
  • Location: Wrigley Field (Chicago)
  • Spread: Michigan -10

Prediction: Northwestern 23, Michigan 20

No. 18 Southern California vs Iowa

  • Date: Saturday, Nov. 15
  • Time: 3:30 p.m. ET
  • Location: Los Angeles Memorial Coliseum (Los Angeles)
  • Spread: USC -6.5

Prediction: Iowa 30, USC 24

No. 19 Virginia vs Duke

  • Date: Saturday, Nov. 15
  • Time: 3:30 p.m. ET
  • Location: Wallace Wade Stadium (Durham, North Carolina)
  • Spread: Duke -6.5

Prediction: Duke 27, Virginia 21

No. 20 Tennessee vs New Mexico State

  • Date: Saturday, Nov. 15
  • Time: 4:15 p.m. ET
  • Location: Neyland Stadium (Knoxville, Tennessee)
  • Spread: Tennessee -38.5

Prediction: Tennessee 49, New Mexico State 14

No. 21 Louisville vs Clemson

  • Date: Saturday, Nov. 15
  • Time: 7:30 p.m. ET
  • Location: L&N Federal Credit Union (Louisville, Kentucky)
  • Spread: Louisville -3.5

Prediction: Louisville 27, Clemson 23

No. 22 Cincinnati vs Arizona

  • Date: Saturday, Nov. 15
  • Time: Noon ET
  • Location: Nippert Stadium (Cincinnati, Ohio)
  • Spread: Cincinnati -6

Prediction: Cincinnati 34, Arizona 31

No. 24 Missouri vs Mississippi State

  • Date: Saturday, Nov. 15
  • Time: 7:45 p.m. ET
  • Location: Memorial Stadium (Columbia, Missouri)
  • Spread: Missouri -6.5

Prediction: Missouri 30, Mississippi State 20

No. 25 James Madison vs App State

  • Date: Saturday, Nov. 15
  • Time: 3:30 p.m. ET
  • Location: Bridgeforth Stadium (Harrisonburg, Virginia)
  • Spread: James Madison -20.5

Prediction: James Madison 35, App State 14

This article originally appeared on USA TODAY: College football Week 12 games, picks, odds and predictions for every Top 25 matchup

Reporting by Ehsan Kassim, USA TODAY / USA TODAY

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