Iowa State Cyclones forward Milan Momcilovic (22) takes a three-point shot around FDU Knights guard guard Eric Parnell (7) during the first half of the season-opener on Nov. 3, 2025, at Hilton Coliseum in Ames.

College hoops are back, and they are in full swing with a headline matchup between two teams from power conferences meeting up to get an early-season test.

The Mississippi State Bulldogs (1-0) and Iowa State Cyclones (2-0) will each travel to Sioux Falls, South Dakota, to square off at the Sanford Pentagon.

If you are looking for some betting advice for the matchup, we've got you covered. Here are the latest odds for the game, courtesy of BetMGM.

Stream Iowa State vs. Mississippi State

Iowa State vs. Mississippi State game odds

All college basketball odds via BetMGM

  • Spread: Iowa State -5.5 (-110), Mississippi State +5.5 (-110)
  • Money Line: Iowa State -235, Mississippi State +195
  • Over-Under: Over 150.5 (-110), Under 150.5 (-110)

Iowa State vs. Mississippi State prediction, pick:

The Cyclones have looked every bit of elite through two games. Sure, it was 88-50 over Fairleigh Dickinson and 102-62 over Grambling, but the impressive part is that Iowa State is shooting 53.4% from the field and 41.4% from behind the arc, led by Milan Momcilovic, who is averaging 20 points per game and shooting 52.6% from deep.

Defensively, Iowa State is holding teams to 45.2% from the field and just 25.6% from three-point range to flex some defensive muscles, and will have to do that once again against Mississippi State guard Josh Hubbard, who poured in 27 points in the Bulldogs' season-opening 86-62 win over North Alabama.

Iowa State will have to be physical and handle the Bulldogs on the board, one area where they have an advantage on paper. Cyclones head coach T.J. Otzelberger will need a strong effort from 6-foot-9, 240-pound Joshua Jefferson, who will be conceding size to Quincy Ballard, the Mississippi State center, standing 7-foot, 260 pounds.

The difference-maker here is the Cyclones' offense. It has too many weapons and can beat Mississippi State from the outside, neutralizing the paint. With the Sanford Pentagon bordering Northwest Iowa, this will be a pseudo-home game for Iowa State in which they take care of business.

Prediction: Iowa State 82, Mississippi State 70

Best Bet: Iowa State -5.5

Iowa State vs. Mississippi State start time, streaming:

Time: 8 p.m. ET

TV Channel: ESPNU

Live Stream: ESPN App

Get more betting analysis and predictions at Sportsbook Wire.

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This article originally appeared on College Sports Wire: Iowa State vs. Mississippi State: College basketball betting odds, prediction

Reporting by Riley Donald, College Sports Wire / College Sports Wire

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