Cleto Escobedo III, the longtime bandleader and saxophonist for Jimmy Kimmel Live, co-creator of the late-night staple’s theme tune, and best friend of its host, has died at the age of 59.

Kimmel broke the sad news on his social accounts, and gave a teary farewell to his good friend Tuesday night (Nov. 11) during his regular show. “Early this morning,” he writes on Instagram, “we lost a great friend, father, son, musician and man, my longtime bandleader Cleto Escobedo III. To say that we are heartbroken is an understatement. Cleto and I have been inseparable since I was nine years old. The fact that we got to work together every day is a dream neither of us could ever have imagined would come true. Cherish your friends and please keep Cleto’s wife, children and parents in your prayers.”

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