Western Conference powers meet in a spotlight matchup as the Oklahoma City Thunder host the Los Angles Lakers on Wednesday. The defending champions have stormed out to an 11-1 start this season, while L.A. is 8-3. The Lakers, however, have the better spread record at 8-3, with OKC at 7-5 ATS. LeBron James (sciatica) remains out for Los Angeles. OKC hasn't released its injury report as it is on the second night of a back-to-back.

Tipoff is set for 9:30 p.m. ET. OKC is a 6.5-point home favorite in the latest Lakers vs. Thunder odds, while the over/under is 230.5. Before making an Thunder vs. Lakers picks, check out the NBA predictions and betting advice from the SportsLine Projection Model .

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