The Arizona Cardinals will be without Marvin Harrison Jr. in Week 11 and potentially beyond after the star wide receiver had an unexpected surgical procedure.

Cardinals head coach Jonathan Gannon announced on Wednesday that Harrison underwent surgery earlier in the week following a bout of appendicitis.

Harrison will not be able to play in Arizona’s home game against the San Francisco 49ers on Sunday.

When asked if Harrison Jr. could miss more than just one game, Gannon replied, "We'll see," according to NFL.com's Kevin Patra .

Cardinals WR Marvin Harrison Jr. underwent surgery for appendicitis and is out for at least this week and possibly longer. — Adam Schefter (@AdamSchefter) November 12, 2025

Marvin Harrison Jr. has been having a good season despite questionable QB play

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