Three panelists engaged in a spirited discussion about longevity and disease prevention at a TIME100 Talks event moderated by TIME senior health correspondent Alice Park in New York City on Wednesday.

Dr. Raj Panjabi, senior partner of the bioplatform innovation company Flagship Pioneering, leading its Preemptive Health and Medicine Initiative; Jillian Michaels, creator of The Fitness App and host of the podcast Keeping It Real: Conversations with Jillian Michaels ; and Dr. Nir Barzilai, director of the Institute for Aging Research at the Albert Einstein College of Medicine and president of the Academy for Health and Lifespan Research, joined Park on stage to discuss topics ranging from vaccines to weight-loss drugs.

During the conversation, Park asked Panjabi, who previously served as

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