San Francisco (6-4) at Arizona (3-6)

Sunday, 4:05 p.m., EDT, Fox

BetMGM NFL Odds: 49ers by 2 1/2.

Series record: 49ers lead 37-31.

Against the spread: 49ers 5-5; Cardinals 5-4.

Last week: Rams beat 49ers 42-26; Seahawks beat Cardinals 44-22.

Last meeting: 49ers beat Cardinals 16-15 on Sept. 21, 2025, in Santa Clara, California.

49ers offense: overall (11), rush (27), pass (1), scoring (23).

49ers defense: overall (21), rush (16), pass (22), scoring (15).

Cardinals offense: overall (21), rush (18t), pass (21), scoring (20).

Cardinals defense: overall (22), rush (18), pass (20), scoring (19).

Turnover differential: 49ers minus-8; Cardinals plus-3.

49ers player to watch

QB Brock Purdy. San Francisco expects to get its starting quarterback back with Purdy on target to return after

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