The Grey’s Anatomy fall finale for season 22 turns “When I Crash” into a brutal hour where Jo Wilson’s pregnancy spirals into heart failure, Richard Webber quietly reveals a cancer diagnosis, and a catastrophic bus accident forces Teddy Altman and Owen Hunt to confront both trauma and their wrecked marriage. Season 22 Episode 6, titled “When I Crash,” aired on Thursday, November 13, 2025, from 10:00–11:00 p.m. EST on ABC, and the ending leaves Jo’s future so uncertain that it instantly reignites fan questions like “ Is Jo leaving Grey’s Anatomy?” and “ Does Jo die in Grey’s Anatomy?” The official winter return is set for January 8, 2026, at 10/9c on ABC, with the episode streaming the next day on Hulu.

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