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Percy Harvin 's Florida home erupted in flames Thursday evening ... triggering a huge response from firefighters, TMZ Sports has learned.

The inferno, which lit up the sky, was captured on video by a neighbor.

It's unclear if 37-year-old Harvin or his family were in the home at the time of the terrifying incident ... but indications are that no one was seriously harmed.

"I can confirm that the Alachua County Sheriff’s Office responded to the report of a structure fire at that residence yesterday evening," a spokesperson for local law enforcement told us.

"Alachua County Fire Rescue responded and handled the incident while we assisted with evacuating nearby residences and closing the roadway."

Harvin's home isn't far from Florida University's campus in Gainesville, where he s

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