Researchers at Dartmouth Hitchcock Medical Center have developed a new test that could diagnose Lyme disease earlier and more accurately than currently available testing methods.

Results presented today at the Association for Molecular Pathology (AMP) 2025 Annual Meeting & Expo show this new test achieved 90.9% sensitivity in a small set of samples. This represents a major improvement when compared to two-tiered serology testing, the current diagnostic standard for Lyme disease, which typically has a sensitivity lower than 50% during early stages, leading to many false negative results in the first six weeks of infection.

Early diagnosis of Lyme disease can significantly reduce the risk of long-term complications affecting the skin, joints, heart, and nervous system. However, many patien

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